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KMID : 0043320200430070755
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Archives of Pharmacal Research
2020 Volume.43 No. 7 p.755 ~ p.764
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Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus
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Wang Na
Dong Xiujuan
Shi Dandan
Li Na
Zhang Qun
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Abstract
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Gestational diabetes mellitus (GDM) is a conditional diabetes which is defined as any degree of glucose intolerance or high blood glucose levels during any phase of pregnancy. It causes chronic severe damage to health of the pregnant women and their offspring. In this study, we aimed to study the protective effects of Cryptotanshinone on GDM-related impairments. We measured blood glucose levels, serum insulin levels, biochemical indexes, oxidative stress, inflammation and the activation of NF-κB signaling pathway in the blood and placenta of GDM mice. It is found that Cryptotanshinone significantly decreased blood glucose levels, oxidative stress, inflammation and NF-κB signaling with an increase of serum insulin levels in the placenta and blood of GDM mice. Taken together, Cryptotanshinone effectively ameliorated GDM, which suggested that Cryptotanshinone could be served as a promising therapeutic drug for GDM patients.
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KEYWORD
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Gestational diabetes mellitus, Cryptotanshinone, Placental, Oxidative stress, Inflammation
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